Zoom: https://unl.zoom.us/j/92732064797
Virtual Seminar: 9:00 - 10:00 AM CST
Probiotics are live beneficial microorganisms that can be consumed in the form of dairy and food products as well as
dietary supplements to promote a healthy balance of gut bacteria in humans. Now, one of the main scientific and
industrial challenges is to identify and select promising strains and formulate multi-strain probiotic blend with
consistent efficacy which is highly dependent on individual dietary regimes, gut environments, and health conditions.
Interestingly, the limitations of current in vivo and in vitro methods for testing probiotic strains can be overcome by in
silico model guided systems biology approach since genome scale metabolic models (GEMs) can be used to describe
and predict their cellular behaviours, metabolic states and community interactions under various gut environments. In
this talk, I will summarize currently available GEMs of microbial strains with probiotic potentials, and present a
knowledge-based platform to evaluate their capabilities on the basis of probiotic criteria in terms of metabolic
characteristics, stability, safety, colonization, postbiotics, interaction with the gut microbiome and variation across diets.
Its applicability is demonstrated by a case study where genome-wide metabolic landscapes in several lactic acid bacteria
(LAB) are systematically evaluated to elucidate diet-induced and strain specific probiotic features. In addition, I will
discuss how their metabolic interactions with the host and gut microbiome can be investigated to propose new strategies
for personalized probiotics design, thereby ameliorating lifestyle diseases.
Friday, March 5th, 2021
Meeting ID: 927 3206 4797 Passcode: 759697
More details at: https://unl.zoom.us/j/92732064797