“Genome-Scale Prediction of RNA binding proteins,” will be presented at 4 p.m. Oct. 17 by Yaoqi Zhou, Indiana University School of Medicine. A reception will be held at 3:30 p.m. The event is at Beadle Center and is open to the public.
A full understanding of the mechanism of post-transcriptional regulation requires genome-scale annotation of all RNA binding proteins. However, detecting protein-RNA interactions is challenging both experimentally and computationally because RNAs are large in number, diverse in cellular location and function, and flexible in structure.
As a result, many RNA-binding proteins (RBPs) remain to be identified. Zhou will talk about a sequence-based technique dedicated for predicting complex structures of protein and RNA by combining fold recognition with binding affinity prediction. The method not only provides a highly accurate complex structure prediction but also detects RNA-binding proteins in high precision with reasonable sensitivity. Its application of human genome reveals many novel RNA binding proteins.
The complete schedule of seminars may be found at http://biotech.unl.edu/
More details at: http://events.unl.edu/2012/10/17/70501/