Laimins to present biotechnology, life sciences seminar

Laimonis (Lou) Laimins
Laimonis (Lou) Laimins

Laimonis (Lou) Laimins, of Northwestern University, will present "Human papillomaviruses and the DNA Damage Response" at 4 p.m., Nov. 6 in E103 Beadle Center (1901 Vine Street). The seminar is free and open to the public.

The differentiation-dependent life cycle of human papillomaviruses is regulated by a variety of mechanisms. Our studies indicate that HPV E7 proteins activate the ATM DNA damage response and that this is important for genome amplification in differentiating epithelial cells.

The E7 protein mediates activation of STAT-5, as well as retention of p63 in suprabasal cells, and both activities are necessary for induction of the DNA damage response.

Additional studies have identified an important role for the SMC1 cohesin proteins in HPV replication. SMC1 proteins are recruited to HPV genomes through interactions with CTCF factors. The interconnection of these mechanisms in regulating viral pathogenesis will be discussed.

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